Background: Mild neurocognitive disorder (mNCD) is one of the degenerative illnesses that leads to memory deficit, and will improvement to dementia. experimental group and a control group. Each participant shall go to the trial middle 7 situations through the 12 weeks of involvement. The follow-up research will be conducted 12 weeks following the intervention ends. The primary final result may be the variance in Seoul verbal learning test-elderly’s edition (SVLT-E) rating from baseline to 12 weeks. Supplementary outcomes include ratings/beliefs for the next factors: SVLT-E, Rey complicated figure check, Digit span check, Korean-Boston naming check, calculation ability, managed oral phrase association check, Korean-color phrase stroop test, digit sign coding, Korean-trail making test-elderly’s version, Korean version of mini mental state exam for dementia screening, euro-qol-5 dimension, pattern identifications tool for cognitive disorders, Korean version of Montreal cognitive assessment, Korean quality of life-Alzheimer disease, computerized tongue image analysis system, blood pressure pulse analyzer, bioelectrical impedance analyzer, AZD-3965 novel inhibtior wearable electroencephalogram device, useful near-infrared spectroscopy program, and cost evaluation. Discussion: This is actually the initial trial analyzing the efficiency of JDH for mNCD. We anticipate this trial provides solid support for wide usage of JDH for mNCD and result in further analysis on organic medicine remedies for mNCD. Trial enrollment amount: KCT0003570 (Signed up in Clinical Study Information Service of the Republic of Korea, https://cris.nih.go.kr/cris/search/search_result_st01.jsp?seq=12669). strong class=”kwd-title” Keywords: herbal medicine, Jujadokseo-hwan, memory space deficit, slight cognitive impairment, slight neurocognitive disorder 1.?Intro Recently, degenerative diseases have a higher prevalence due to extended existence expectancies. Among them, dementia AZD-3965 novel inhibtior has the fourth highest mortality rate after cancer, heart disease, and stroke. Currently, slight neurocognitive disorder (mNCD) is known as a precursor for dementia.[1] However, there is no apparent cure and a variety of alternate treatments are being evaluated.[2,3] Numerous clinical studies possess reported using herbal medicines to improve memory space and cognition, although no well-designed randomized controlled tests have been performed so far.[4C6] Jujadokseo-hwan (JDH, ZhuziDushu Wan in Chinese) is a traditional herbal medicine formulation listed in Uihak-ipmun (Yixue Rumen in Chinese). It is composed of 7 natural parts: Acori Graminei Rhizoma, Angelica Gigantis Radix, Citri Unshius Pericarpium, Ginseng Radix, Glycyrrhizae Radix et Rhizoma, Poria Sclerotium, and Poly galae Radix. In South Korea, a tablet form of JDH is definitely approved for memory space deficit (amnesia) from the Korean Ministry of Food and Drug Security. Two experimental studies investigated the effects of JDH on the brain ability and oxidative stress and found that JDH improved mind ability, learning, and memory space, and also shown a neuroprotective effect.[7,8] We plan to conduct a randomized, double-blind, placebo-controlled, parallel;-group, multi-central trial to evaluate the security and effectiveness of JDH in individuals with mNCD. 2.?Methods 2.1. Objectives The main objective of this study is to evaluate the safety and efficacy of JDH compared to placebo for treating mNCD. 2.2. Study design and setting This study is designed as a randomized, double-blind, placebo-controlled, parallel-group, multi-center trial. The clinical trial sites are as follows: Dunsan Korean medicine Hospital of Daejeon University, Wonkwang university Sanbon hospital, and Wonkwang university oriental medical hospital, Jeonju. The anticipated number of eligible participants is 80. Subjects will be divided into 2 equal groups: the JDH group (experimental group) and the placebo group (control group). Each group will be administered JDH or placebo 3 times day for 12 weeks (84 days). After the 12-week follow-up period, participants will end up being instructed to go to the trial middle once for effectiveness and protection assessments. The primary result may be the Seoul verbal learning test-elderly edition (SVLT-E)[9] score adjustable. The secondary results include scoring factors through the SVLT-E, Rey complicated figure check (RCFT),[10] digit period check (DST),[11] Korean-Boston naming check (K-BNT),[12] computation ability, controlled dental word association check (COWAT),[13] Korea-Color term stroop check (K-CWST),[14] digit mark coding (DSC),[15] Korean trail-making test-elderly’s edition AZD-3965 novel inhibtior (K-TMT-E),[16] Mini-Mental condition exam for dementia testing (MMSE-DS),[17] EuroQol-5 Sizing (EQ-5D),[18] Design identifications device for cognitive disorders (PIT-C),[19] Montreal cognitive assessment-Korean edition (MoCA-K),[20] and Korean FGF21 quality of life-Alzheimer’s disease (KQOL-AD) size.[21] Other supplementary outcomes consist of measured ideals from computerized tongue picture analysis program (CTIS, Gadget name: TAS-4000), blood AZD-3965 novel inhibtior circulation pressure pulse analyzer (BPPA, Gadget name: DMP-life), bioelectrical impedance analyzer (BIA, Gadget name: InBody S-10), wearable electroencephalogram gadget (WED, Gadget name: neuroNicle.