Pleural tuberculosis (TB) as well as lymphatic TB constitutes more than half of all extrapulmonary cases. CCR5 the primary receptor used by MCP-2/CCL8 is mostly expressed on pleural CD4+ T lymphocytes. Furthermore we found that infection with either Bacillus Calmette-Guérin (BCG) or H37Rv induced production of MCP-2/CCL8 at both transcriptional and protein level in Mouse… Continue reading Pleural tuberculosis (TB) as well as lymphatic TB constitutes more than
Category: Kynurenine 3-Hydroxylase
The four serotypes of dengue virus (DENV-1 to -4) represent the
The four serotypes of dengue virus (DENV-1 to -4) represent the most prevalent mosquito-borne viral pathogens in humans. While there are several promising vaccine Nordihydroguaiaretic acid candidates in clinical trials approved vaccines or antivirals are not yet available. Here we describe the identification and characterization of a spiropyrazolopyridone as a novel inhibitor of DENV by… Continue reading The four serotypes of dengue virus (DENV-1 to -4) represent the
The influenza neuraminidase (NA) inhibitors zanamivir oseltamivir and peramivir were all
The influenza neuraminidase (NA) inhibitors zanamivir oseltamivir and peramivir were all designed based on the knowledge that this transition state analogue of the cleaved sialic acid 2 2 3 N-acetyl neuraminic acid (DANA) was a weak inhibitor of NA. of substrate and IC50s were calculated after LCI-699 each 10 min interval up to 60 min.… Continue reading The influenza neuraminidase (NA) inhibitors zanamivir oseltamivir and peramivir were all