Background and purpose: Nitric oxide (NO) controls numerous physiological processes by activation of its receptor guanylyl cyclase (sGC) leading to the accumulation of 3′-5′ cyclic guanosine monophosphate (cGMP). of cGMP and inactivation of NO were both inhibited by the CaM antagonists ruling out increased lack of cGMP or NO as explanations. Rather calmidazolium straight inhibited… Continue reading Background and purpose: Nitric oxide (NO) controls numerous physiological processes by
Category: M1 Receptors
Odors elicit spatio-temporal patterns of activity in the brain. For several
Odors elicit spatio-temporal patterns of activity in the brain. For several odorants and receptor types the ORN response dynamics normalized by the peak response are impartial of stimulus intensity for a large portion of the neuron’s dynamic range. Adaptation to a background odor changes the gain and dynamic range of the response but does not… Continue reading Odors elicit spatio-temporal patterns of activity in the brain. For several
Proteasome inhibitors can resensitize cells that are resistant to tumors necrosis
Proteasome inhibitors can resensitize cells that are resistant to tumors necrosis factor-related apoptotic-inducing ligand (TRAIL)-mediated apoptosis. treatment with bortezomib or MG132 resulted in an increase of death receptor (DR) 5 and Bik at protein levels but experienced no effects on protein levels of DR4 Bax Bak Bcl-2 Bcl-XL or Flice-inhibitory protein (FLIP). Moreover c-Jun N-terminal… Continue reading Proteasome inhibitors can resensitize cells that are resistant to tumors necrosis