Acute promyelocytic leukemia (APL) results from a chromosomal translocation that gives rise to the leukemogenic fusion protein PML-RAR (promyelocytic leukemiaCretinoic acid receptor). treatment strategy for ATRA-resistant APL. Introduction Desperate promyelocytic leukemia (APL) represents around 10% of all severe myeloid leukemias in adults (Melnick and Licht, 1999; Zelent gene on chromosome 15 and are known to… Continue reading Acute promyelocytic leukemia (APL) results from a chromosomal translocation that gives