Background The K65R substitution in human being immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) may be the main resistance mutation selected in patients treated with first-line antiretroviral tenofovir disoproxil fumarate (TDF). WT and K65R RT. This substitution causes small adjustments in the effectiveness of EFdA incorporation with regards 1048973-47-2 manufacture to the organic dATP… Continue reading Background The K65R substitution in human being immunodeficiency virus type 1