Akt is an integral signalling molecule that was present to become down-regulated in chronic wounds. CCN2 is certainly adding to this impact. Additional experiments demonstrated that CCN2 induces phosphorylation of ERK1/2, Ets1 and c-Jun. In keeping with the stimulatory function of ERK1/2/Ets1 in the appearance of MMP1, the ERK1/2 inhibitor UO126 avoided the phosphorylation of… Continue reading Akt is an integral signalling molecule that was present to become