Doxorubicin-overproducing strains of ATCC 29050 can be acquired through manipulation from the genes around the doxorubicin (DXR) gene cluster which has polyketide synthase gene, the putative ketoreductase gene, cytochrome P-450 gene. Hutchinson, J. Bacteriol. 178:7316C7321, 1996) triple mutant. Overexpression of within a mutant led to the deposition of DXR precursors rather than within a notable… Continue reading Doxorubicin-overproducing strains of ATCC 29050 can be acquired through manipulation from