Fetal contact with xenobiotics can be restricted by transporters in the interface between maternal and fetal blood circulation. higher mRNA levels of the efflux transporters Mrp2 (7-fold), Mrp4 (5-fold), Mrp5 (3-fold), Mrp6 (12-fold), Bcrp (2-fold), and Mate-1 (7-fold) compared to placenta. Western blot of Mrp2, Mrp4, Mrp6, and Bcrp confirmed higher manifestation in fetal membranes.… Continue reading Fetal contact with xenobiotics can be restricted by transporters in the