Tobacco-specific nitrosamines, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and gene in the BER and NER deficient cell lines. adducts accumulate in pulmonary Type II cells and correlate with lung tumor formation in NNK-treated rats (14). Finally, pyridyloxobutyl DNA adducts also build up in normal lung tissues of lung cancer patients (15), indicating that the formation and persistence of these… Continue reading Tobacco-specific nitrosamines, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and gene in the BER and NER