Severe stimulation of cardiac -adrenoceptors is essential to raising cardiac function under stress; nevertheless, sustained -adrenergic arousal continues to be implicated in pathological myocardial remodeling and heart failure. receptor activation. Jointly, our data reveal a paracrine function for secreted cAMP in intercellular signaling in the myocardium, and we postulate that secreted cAMP could also constitute… Continue reading Severe stimulation of cardiac -adrenoceptors is essential to raising cardiac function