It has been suggested that T cell immunoglobulin mucin (Tim)-1 expressed on T cells serves to positively costimulate T cell responses. Both antibodies bound to closely related epitopes in the IgV domain of the Tim-1 molecule but AescinIIB the activating antibody had an avidity for Tim-1 that was 17 times higher than the inhibitory antibody.… Continue reading It has been suggested that T cell immunoglobulin mucin (Tim)-1 expressed