Excess and ectopic smooth muscle cells (SMCs) are central to cardiovascular disease pathogenesis but underlying mechanisms are poorly defined. in hypoxia-induced PH they express the pluripotency factor Kruppel-like element 4 (KLF4) and in each arteriole one of these migrates distally dedifferentiates and clonally expands providing rise towards the distal SMCs. Furthermore hypoxia-induced manifestation from the… Continue reading Excess and ectopic smooth muscle cells (SMCs) are central to cardiovascular