The developmentally important hedgehog (Hh) pathway is activated by binding of Hh to patched (Ptch1), releasing smoothened (Smo) as well as the downstream transcription factor glioma associated (Gli) from inhibition. mediate the Smo inhibition. Certainly, the inhibition of 3-hydroxysteroid synthesis impaired Ptch1 actions on Smo, whereas adding the 3-hydroxysteroid (pro-)supplement D3 towards the moderate efficiently… Continue reading The developmentally important hedgehog (Hh) pathway is activated by binding of