Secreted frizzled-related protein 1 (sFRP1) is an antagonist of Wnt PIK-294 signaling an important pathway in maintaining bone homeostasis. for 2 weeks increased trabecular bone volume in WT mice (females: +30% to 50%; males: +35% to 150%) compared with mice (females: +5%; males: +18% to 54%). Percentage increases in bone formation also were lower in… Continue reading Secreted frizzled-related protein 1 (sFRP1) is an antagonist of Wnt PIK-294