Alternative premRNA splicing is a major mechanism to generate diversity of gene products. the relevant Numb splice isoform was sufficient to rescue, in an isoform-specific manner, postmitotic neurons from defects in differentiation caused by Rbfox3 depletion. Thus, Rbfox3-dependent alternative splicing plays an important role in the progression of neuronal differentiation during vertebrate development. Introduction Alternative… Continue reading Alternative premRNA splicing is a major mechanism to generate diversity of