Supplementary MaterialsSupplementary Information 41467_2018_5772_MOESM1_ESM. MBCs are prepositioned inside a subcapsular niche in lymph nodes where, upon reactivation by antigen, they rapidly proliferate and differentiate into antibody-secreting plasma cells in the subcapsular proliferative foci (SPF). This novel structure is enriched for signals provided by T follicular helper cells and antigen-presenting subcapsular sinus macrophages. Compared with contemporaneous… Continue reading Supplementary MaterialsSupplementary Information 41467_2018_5772_MOESM1_ESM. MBCs are prepositioned inside a subcapsular niche