This paper presents an up-to-date overview of the data indicating that atypical neurotransmitters such as for example nitric oxide (NO) and endocannabinoids (eCBs) play a significant role in the regulation of aversive responses in the periaqueductal grey (PAG). which might explain the generally bell-shaped dose-response curves noticed with medications that action on NO- or CB1-mediated… Continue reading This paper presents an up-to-date overview of the data indicating that
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Beta-amyloid (Aβ) in brain is a major factor involved in Alzheimer’s
Beta-amyloid (Aβ) in brain is a major factor involved in Alzheimer’s disease (AD) that results in severe memory deficit. site but not the Swe mutant site of APP for Aβ production explains the distinct inhibitor responses in the different AD mouse models. In contrast to cathepsin B the BACE1 β-secretase prefers to cleave the Swe… Continue reading Beta-amyloid (Aβ) in brain is a major factor involved in Alzheimer’s