Background Prior observations demonstrate that em Cftr /em -null cells and tissues exhibit alterations in cholesterol processing including perinuclear cholesterol accumulation, improved em de novo /em synthesis, and a rise in plasma membrane cholesterol accessibility in comparison to crazy type controls. recognition. Appearance of wt CFTR in CF epithelial cells reverts membrane cholesterol to WT… Continue reading Background Prior observations demonstrate that em Cftr /em -null cells and