The acquisition of endocrine resistance is a common obstacle in endocrine therapy of patients with oestrogen receptor- (ER)-positive breast tumours. HA-PHB2 co-immunoprecipitated with BIG31C434, BIG31C250 and full-length BIG3 (Fig. 1b), suggesting that the 101C250th amino acid region of BIG3 is minimally required for its interaction with PHB2. Figure 1 Identification of the BIG3CPHB2 interacting region.… Continue reading The acquisition of endocrine resistance is a common obstacle in endocrine