Pioneer transcription factors recognise and bind their target sequences in inaccessible chromatin to establish new transcriptional networks throughout development and cellular reprogramming. loss of OCT4 manifestation (Niwa et al., 2000). It is buy SNT-207858 known that prolonged removal of OCT4 in ESCs results in loss of pluripotency and cellular differentiation (Niwa et al., 2000; Adachi… Continue reading Pioneer transcription factors recognise and bind their target sequences in inaccessible