Lucanthone and hycanthone are thioxanthenone DNA intercalators found in the 1980s while antitumor brokers. for lucanthone/10 nM for hycanthone. APE1 constructions reveal a hydrophobic pocket where hydrophobic little substances like thioxanthenones can bind, and our modeling tests confirmed such docking. Round dichroism spectra uncovered switch in the BG45 helical framework of APE1 in the current… Continue reading Lucanthone and hycanthone are thioxanthenone DNA intercalators found in the 1980s