During early pancreatic development Notch signaling represses differentiation of endocrine cells and promotes proliferation of Nkx6-1+Ptf1a+ multipotent progenitor cells (MPCs). along with a matching lack of Neurog3+ endocrine β-cells and progenitors. An accompanying upsurge in Nkx6-1?Ptf1a+ and amylase+ cells occupying the proximal domain shows that proximal cells adopt a distal destiny in the lack of… Continue reading During early pancreatic development Notch signaling represses differentiation of endocrine cells