Purpose One of the major obstacles in understanding the molecular mechanisms underlying the transition of prostate cancer growth from Cilomilast androgen dependency to hormone-refractory state is the lack of androgen-regulated and tumorigenic human prostate cancer cell lines. in CWR22Pc cells. The AR in CWR22Pc cells contains the H874Y mutation but not the exon 3 duplication… Continue reading Purpose One of the major obstacles in understanding the molecular mechanisms