In pancreatic -cells, uptake of Ca2+ into mitochondria facilitates metabolism-secretion coupling by activation of different matrix enzymes, facilitating ATP generation by oxidative phosphorylation and thus, in turn, augmenting insulin release. admittance via L-type stations. In comparison, knockdown of UCP2 and LETM1 specifically decreased mitochondrial Ca2+ uptake in response to either intracellular Ca2+ launch or Ca2+… Continue reading In pancreatic -cells, uptake of Ca2+ into mitochondria facilitates metabolism-secretion coupling