The chemokine receptor CXCR2 is a key mediator of neutrophil migration that also plays a role in tumor development. Ly6G+ cell depletion purged CXCR2-dependent tumor-associated leukocytes suppressed established skin tumor growth and colitis-associated tumorigenesis and reduced adenoma formation. CXCR2 is thus a potent protumorigenic chemokine receptor that directs recruitment of tumor-promoting leukocytes into tissues during… Continue reading The chemokine receptor CXCR2 is a key mediator of neutrophil migration