The low-molecular-weight compound APR-246 (PRIMA-1MET) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. cells lacking mutant p53. is sufficient to reactivate mutant p53.21 MIRA-1 and STIMA-1 also have Michael acceptor activity, although their covalent modification of p53 has not yet been confirmed. The observation that MQ binds covalently to… Continue reading The low-molecular-weight compound APR-246 (PRIMA-1MET) restores wild-type conformation and function to