The activity of phosphodiesterase-5 (PDE5) is specific for cGMP and is regulated by cGMP binding to GAF-A in its regulatory website. GAF-A GAF-B and the N-terminal loop which may serve as a relay of the cGMP transmission from GAF-A to GAF-B. N-terminal loop FGFR3 98-147 was actually associated with GAF-B domains of the dimer. Biochemical… Continue reading The activity of phosphodiesterase-5 (PDE5) is specific for cGMP and is