Proteasome inhibitors can resensitize cells that are resistant to tumors necrosis factor-related apoptotic-inducing ligand (TRAIL)-mediated apoptosis. treatment with bortezomib or MG132 resulted in an increase of death receptor (DR) 5 and Bik at protein levels but experienced no effects on protein levels of DR4 Bax Bak Bcl-2 Bcl-XL or Flice-inhibitory protein (FLIP). Moreover c-Jun N-terminal… Continue reading Proteasome inhibitors can resensitize cells that are resistant to tumors necrosis