We’ve shown recently that glucose-dependent insulinotropic polypeptide (GIP), however, not glucagon-like peptide 1 (GLP-1) augments H+ peptide cotransporter (PepT1)-mediated peptide absorption in murine jejunum. whereas neither calphostin C (a potent PKC inhibitor) nor BAPTA (an intracellular Ca2+ chelator) pretreatment affected the GIP-augmented Gly-Sar uptake in IEC-6/CDX2 cells. The downstream metabolites Epac (control vs. Epac agonist:… Continue reading We’ve shown recently that glucose-dependent insulinotropic polypeptide (GIP), however, not glucagon-like