Gαq directly activates p63RhoGEF and closely related catalytic domains within Trio and Kalirin thereby linking Gq-coupled receptors to the activation of RhoA. and provide evidence that Gαq overcomes this inhibition by altering the conformation of the α6-αN linker that joins the DH and PH domains a region that forms direct contacts with RhoA. We also… Continue reading Gαq directly activates p63RhoGEF and closely related catalytic domains within Trio