Several HMGB1-specific antagonists have provided beneficial results in multiple models of inflammatory disease-preclinical trials including arthritis. Effects on the secretion were assessed in cultures supplemented with dexamethasone cortisone chloroquine gold sodium thiomalate methotrexate colchicine etanercept or anakinra. Pharmacologically relevant doses of dexamethasone gold sodium thiomalate and chloroquine inhibited the extracellular release of HMGB1 in a… Continue reading Several HMGB1-specific antagonists have provided beneficial results in multiple models of
Tag: Gossypol
measurement of nitric oxide in lipopolysaccharide (LPS)-stimulated RAW 264. iNOS-negative counterparts
measurement of nitric oxide in lipopolysaccharide (LPS)-stimulated RAW 264. iNOS-negative counterparts [12]. In this respect the discovery of iNOS inhibitors is important for the treatment of inflammatory diseases as well as the prevention of cancers. During the course of our Gossypol search for bioactive natural products from marine-derived actinomycete strains the crude extract of our… Continue reading measurement of nitric oxide in lipopolysaccharide (LPS)-stimulated RAW 264. iNOS-negative counterparts