Intramembrane proteases catalyze the signal-generating step of various cell signaling pathways and continue to be implicated in diseases ranging from malaria illness to Parkinsonian neurodegeneration1-3. deleting the amino-terminal EF-hands triggered proteolysis prematurely while residues in cytoplasmic loops linking distal transmembrane segments mediated calcium activation. Rhomboid regulation was not orchestrated by either dimerization or substrate relationships.… Continue reading Intramembrane proteases catalyze the signal-generating step of various cell signaling pathways