History SIRT1 a NAD-dependent deacetylase has diverse functions in a variety of organs such as regulation of endocrine function and metabolism. SIRT1 knockdown decreased the levels of deacetylated PIP5Kγ PI(4 5 and reduced the secretion of TSH from pituitary cells. These results were also observed in SIRT1-knockout mice. Conclusions/Significance Our findings indicated that this control… Continue reading History SIRT1 a NAD-dependent deacetylase has diverse functions in a variety