Ca2+ regulation by PMCA4b in cardiomyocytes Cardiomyocyte contraction requires severe changes in cytoplasmic Ca2+ concentration. hypertrophy. By contrast the mice showed T0070907 reduced pathologic cardiac hypertrophy in two models of the disease (including transverse aortic constriction [TAC] a style of high bloodstream pressure-induced cardiac hypertrophy). In keeping with this mice missing PMCA4b exhibited elevated cardiac… Continue reading Ca2+ regulation by PMCA4b in cardiomyocytes Cardiomyocyte contraction