The gene encodes the 1A subunit of voltage-gated CaV2. In this mouse model with a cell type-specific ablation of CaV2.1 channels, we show that ablation of CaV2.1 channels restricted to Purkinje cells is sufficient to cause cerebellar ataxia. We demonstrate that spatial ablation of CaV2.1 channels may help in unraveling mechanisms of human disease. Electronic… Continue reading The gene encodes the 1A subunit of voltage-gated CaV2. In this