In vivo GITR ligation has been demonstrated to augment T-cell-mediated anti-tumor immunity previously, however the underlying mechanisms of this activity, particularly its in vivo effects on CD4+ foxp3+ regulatory Capital t cells (Tregs), possess not been elucidated completely. alter systemic Treg frequencies nor abrogate the inbuilt suppressive activity of Tregs within the tumor-draining lymph node,… Continue reading In vivo GITR ligation has been demonstrated to augment T-cell-mediated anti-tumor