The Wnt planar cell polarity (Wnt/PCP) pathway signals through small Rho-like GTPases to modify the cytoskeleton. GTPase Rac1 or by dominant-negative Rac1. In itself knockdown of Rac1 impaired cytoskeletal integrity and reduced cell-cell adhesion. We found that Vangl2 bound and re-distributed Rac1 within the cells but did not alter Rac1 activity. Moreover both A 740003… Continue reading The Wnt planar cell polarity (Wnt/PCP) pathway signals through small Rho-like