Supplementary MaterialsS1 Dataset: wwPDB validation report. site S195 with high potency and significant selectivity over other trypsin-like serine proteases. The compound inhibits the binding of a peptide substrate with both clot-bound and free thrombin with nanomolar potency. Compound 1 is a low micromolar inhibitor of thrombin activity against endogenous substrates such as fibrinogen and a… Continue reading Supplementary MaterialsS1 Dataset: wwPDB validation report. site S195 with high potency