Several HMGB1-specific antagonists have provided beneficial results in multiple models of inflammatory disease-preclinical trials including arthritis. Effects on the secretion were assessed in cultures supplemented with dexamethasone cortisone chloroquine gold sodium thiomalate methotrexate colchicine etanercept or anakinra. Pharmacologically relevant doses of dexamethasone gold sodium thiomalate and chloroquine inhibited the extracellular release of HMGB1 in a… Continue reading Several HMGB1-specific antagonists have provided beneficial results in multiple models of