A multivalent magnetic resonance imaging agent based on a 2-hydroxypropyl-β-cyclodextrin (HPCD):Pluronic F127 polyrotaxane carrier has been synthesized and its blood pool contrast properties characterized. into the bloodstream where they can provoke nephrogenic systemic fibrosis (NSF) and additional cytotoxic reactions as has been observed for low molecular excess weight acyclic Gd3+-DTPA constructs.14 Additionally many of these… Continue reading A multivalent magnetic resonance imaging agent based on a 2-hydroxypropyl-β-cyclodextrin (HPCD):Pluronic