Objective A dramatic loss of aggrecan proteoglycan from cartilage is associated with osteoarthritis. vesicles. Following trypsinization, the intracellular build up of both epitopes was clearly visible. IL-1 treatment improved extracellular as well as intracellular ITEGE epitope build up. Once internalized, the ITEGE neoepitope became localized within the nucleus and displayed little colocalization with HA, DIPEN,… Continue reading Objective A dramatic loss of aggrecan proteoglycan from cartilage is associated