Scid mice develop a severe, chronic, and lethal IBD 3C6 months after engraftment of gut wall from immunocompetent congenic donors, induced by donor-derived CD4+ T cells migrating from the graft [7]. mice. Immunohistochemistry revealed that this multinucleated giant cells observed in the gut wall of diseased mice did not represent haematopoietic foci, but were derived… Continue reading Scid mice develop a severe, chronic, and lethal IBD 3C6 months