The controversial nature of the CB1 receptor antagonist SR141716A in the guinea-pig small intestine was investigated by comparing it with four analogues of Δ8-tetrahydrocannabinol (Δ8-THC): O-1184 O-1238 O-584 and O-1315. CB1 binding sites in this tissue. There Pacritinib (SB1518) was no evidence of antagonism of endocannabinoids thus supporting the hypothesis that in this tissue SR141716A… Continue reading The controversial nature of the CB1 receptor antagonist SR141716A in the