The nuclear export of the influenza A virus ribonucleoprotein (vRNP) is vital for virus replication. The nuclear export of NES3 was CRM1 reliant whereas that of NES2 or NES1 was CRM1 independent. Inactivation of the NESs resulted in a standard nuclear build up of PSI-6130 NP. Mutation of most 3 NP-NESs impaired viral replication significantly.… Continue reading The nuclear export of the influenza A virus ribonucleoprotein (vRNP) is