Taxanes exert their antitumor impact via stabilizing microtubule dynamics and initiating G2/M arrest in malignancy cells followed by apoptotic cell death. anti-apoptotic proteins to activate Bax and Bak and commit the cell to apoptotic death. Bim and either Puma or Bmf are required for paclitaxel toxicity. While prior PTK787 2HCl mechanisms of apoptosis induced by… Continue reading Taxanes exert their antitumor impact via stabilizing microtubule dynamics and initiating