Enteropathogenic (EPEC) binding to human intestinal cells triggers the formation of disease-associated actin rich structures called pedestals. major pathway to actin polymerization mediated by the actin-related protein (Arp) 2/3 complex. Previous studies ETC-1002 with Nck-deficient mouse embryonic fibroblasts (MEFs) identified a key role for Nck in pedestal formation presumed to reflect a lack of N-WASP… Continue reading Enteropathogenic (EPEC) binding to human intestinal cells triggers the formation of