Checkpoint kinase Chk1 is constitutively active in many malignancy cell types and new generation Chk1 inhibitors show marked antitumor activity as single brokers. that Chk1 inhibition activated PP2A by decreasing the transcription of CIP2A a chief inhibitor of PP2A activity. Inhibition of malignancy cell clonogenicity by Chk1 inhibition could be rescued in vitro either by… Continue reading Checkpoint kinase Chk1 is constitutively active in many malignancy cell types