The chondrocytes of articular cartilage synthesise several proteinases which are capable of degrading the component molecules of this specialized extracellular matrix. of proteolytic cleavage which occur at Asn341-Phe342 and Glu373-Ala374. Whilst cleavage in the second option site is attributed to an unfamiliar ‘aggrecanase’ the Asn341-Phe342 relationship is readily cleaved by many of the known matrix… Continue reading The chondrocytes of articular cartilage synthesise several proteinases which are capable