Aim The purpose of the study was to evaluate the pharmacokinetics of theophylline administered alone and in combination with donepezil HCl following multiple-dose administration of both medicines in healthy volunteers. Treatment periods were separated by a 3-week drug-free washout. Plasma concentrations of theophylline were determined by HPLC with UV detection. Results No statistically significant variations… Continue reading Aim The purpose of the study was to evaluate the pharmacokinetics