Acetylcholinesterase (AChE) is normally a remarkably efficient serine hydrolase responsible for the termination of impulse signaling at cholinergic synapses. to the product the orientation of His447 ring needs to be adjusted very slightly and then the proton transfers from His447 to the product and the break of the scissile bond happen spontaneously. For the three-pronged… Continue reading Acetylcholinesterase (AChE) is normally a remarkably efficient serine hydrolase responsible for